Details

Bioinformatics

4. Aufl.

von: Andreas D. Baxevanis, Gary D. Bader, David S. Wishart
99,99 €
Verlag:	Wiley
Format:	EPUB
Veröffentl.:	21.02.2020
ISBN/EAN:	9781119335955
Sprache:	englisch
Anzahl Seiten:	656

In den Warenkorb

Als Gutschein

DRM-geschütztes eBook, Sie benötigen z.B. Adobe Digital Editions und eine Adobe ID zum Lesen.

Beschreibungen

Titelbeschreibung

Praise for the third edition of Bioinformatics "This book is a gem to read and use in practice." —Briefings in Bioinformatics "This volume has a distinctive, special value as it offers an unrivalled level of details and unique expert insights from the leading computational biologists, including the very creators of popular bioinformatics tools." —ChemBioChem "A valuable survey of this fascinating field. . . I found it to be the most useful book on bioinformatics that I have seen and recommend it very highly." —American Society for Microbiology News "This should be on the bookshelf of every molecular biologist." —The Quarterly Review of Biolog" The field of bioinformatics is advancing at a remarkable rate. With the development of new analytical techniques that make use of the latest advances in machine learning and data science, today’s biologists are gaining fantastic new insights into the natural world’s most complex systems. These rapidly progressing innovations can, however, be difficult to keep pace with. The expanded fourth edition of the best-selling Bioinformatics aims to remedy this by providing students and professionals alike with a comprehensive survey of the current field. Revised to reflect recent advances in computational biology, it offers practical instruction on the gathering, analysis, and interpretation of data, as well as explanations of the most powerful algorithms presently used for biological discovery. Bioinformatics, Fourth Edition offers the most readable, up-to-date, and thorough introduction to the field for biologists at all levels, covering both key concepts that have stood the test of time and the new and important developments driving this fast-moving discipline forwards. This new edition features: <ul> <li>New chapters on metabolomics, population genetics, metagenomics and microbial community analysis, and translational bioinformatics</li> <li>A thorough treatment of statistical methods as applied to biological data</li> <li>Special topic boxes and appendices highlighting experimental strategies and advanced concepts</li> <li>Annotated reference lists, comprehensive lists of relevant web resources, and an extensive glossary of commonly used terms in bioinformatics, genomics, and proteomics</li> </ul> Bioinformatics is an indispensable companion for researchers, instructors, and students of all levels in molecular biology and computational biology, as well as investigators involved in genomics, clinical research, proteomics, and related fields.

Inhaltsverzeichnis

Foreword vii Preface ix Contributors xi About the Companion Website xvii 1 Biological Sequence Databases 1 Andreas D. Baxevanis 2 Information Retrieval from Biological Databases 19 Andreas D. Baxevanis 3 Assessing Pairwise Sequence Similarity: BLAST and FASTA 45 Andreas D. Baxevanis 4 Genome Browsers 79 Tyra G. Wolfsberg 5 Genome Annotation 117 David S. Wishart 6 Predictive Methods Using RNA Sequences 155 Michael F. Sloma, Michael Zuker, and David H. Mathews 7 Predictive Methods Using Protein Sequences 185 Jonas Reeb, Tatyana Goldberg, Yanay Ofran, and Burkhard Rost 8 Multiple Sequence Alignments 227 Fabian Sievers, Geoffrey J. Barton, and Desmond G. Higgins 9 Molecular Evolution and Phylogenetic Analysis 251 Emma J. Griffiths and Fiona S.L. Brinkman 10 Expression Analysis 279 Marieke L. Kuijjer, Joseph N. Paulson, and John Quackenbush 11 Proteomics and Protein Identification by Mass Spectrometry 315 Sadhna Phanse and Andrew Emili 12 Protein Structure Prediction and Analysis 363 David S. Wishart 13 Biological Networks and Pathways 399 Gary D. Bader 14 Metabolomics 437 David S. Wishart 15 Population Genetics 481 Lynn B. Jorde and W. Scott Watkins 16 Metagenomics and Microbial Community Analysis 505 Robert G. Beiko 17 Translational Bioinformatics 537 Sean D. Mooney and Stephen J. Mooney 18 Statistical Methods for Biologists 555 Hunter N.B. Moseley Appendices 583 Glossary 591 Index 609

Autorenportrait

EDITED BY ANDREAS D. BAXEVANIS, PhD, Director of Computational Biology for the National Institutes of Health's Intramural Research Program and a Senior Scientist leading the Computational Genomics Unit at the NIH's National Human Genome Research Institute, Bethesda, MD, USA. GARY D. BADER, PhD, Ontario Research Chair in Biomarkers of Disease and Professor at the Donnelly Centre and the Departments of Molecular Genetics and Computer Science at the University of Toronto, Toronto, ON, Canada. DAVID S. WISHART, PhD, Distinguished University Professor in the Departments of Biological Sciences and Computing Science at the University of Alberta, Edmonton, AB, Canada.

Back cover copy

A CUTTING-EDGE GUIDE TO BIOINFORMATICS AND ITS ROLE IN MODERN BIOLOGY The field of bioinformatics is advancing at a remarkable rate. With the development of new analytical techniques that make use of the latest advances in machine learning and data science, today's biologists are gaining fantastic new insights into the natural world's most complex systems. These rapidly progressing innovations can, however, be difficult to keep pace with. The expanded fourth edition of the best-selling Bioinformatics aims to remedy this by providing students and professionals alike with a comprehensive survey of the current field. Revised to reflect recent advances in computational biology, it offers practical instruction on the gathering, analysis, and interpretation of data, as well as explanations of the most powerful algorithms presently used for biological discovery. Bioinformatics, Fourth Edition offers the most readable, up- to-date, and thorough introduction to the field for biologists at all levels, covering both key concepts that have stood the test of time and the new and important developments driving this fast-moving discipline forward. This new edition features: <ul> <li>New chapters on metabolomics, population genetics, metagenomics and microbial community analysis, and translational bioinformatics</li> <li>A thorough treatment of statistical methods as applied to biological data</li> <li>Special topic boxes and appendices highlighting experimental strategies and advanced concepts</li> <li>Annotated reference lists, comprehensive lists of relevant web resources, and an extensive glossary of commonly used terms in bioinformatics, genomics, and proteomics</li> </ul> Bioinformatics is an indispensable companion for researchers, instructors, and students of all levels in molecular biology and computational biology, as well as investigators involved in genomics, clinical research, proteomics, and related fields. Praise for the Third Edition of BIOINFORMATICS "This book is a gem to read and use in practice." —Briefings in Bioinformatics "This volume has a distinctive, special value as it offers an unrivalled level of details and unique expert insights from the leading computational biologists, including the very creators of popular bioinformatics tools." —ChemBioChem "A valuable survey of this fascinating field. . . I found it to be the most useful book on bioinformatics that I have seen and recommend it very highly." —American Society for Microbiology News "This should be on the bookshelf of every molecular biologist." —The Quarterly Review of Biology