Details

<p>Contributors vii</p> <p>Preface xi</p> <p>Acknowledgments xiii</p> <p>Dedication xv</p> <p>Abbreviations and Acronyms xvii</p> <p><b>Part One </b><b>Nanotoxicology </b><b>1</b></p> <p>1 Testing Nanotoxicity: An Update of New and Traditional Methods 3<br /> <i>Anna G. Cattaneo, Rosalba Gornati, Giovanni Bernardini, Enrico Sabbioni, Luigi Manzo and Mario Di Gioacchino</i></p> <p>2 Considerations for <i>In Vitro </i>Nanotoxicity Testing 35<br /> <i>Athena M. Keene, Simona Bancos and Katherine M. Tyner</i></p> <p>3 <i>In Vivo </i>Evaluation of Acute and Chronic Nanotoxicity 65<br /> <i>Hayley Nehoff, Neha N. Parayath, Sebastien Taurin and Khaled Greish</i></p> <p>4 Genotoxicity of Silver Nanoparticles 87<br /> <i>Yan Li and Tao Chen</i></p> <p>5 Immunotoxicology of Nanomaterials 99<br /> <i>Courtney M. Lappas</i></p> <p>6 Neurotoxicity of Nanoparticles 111<br /> <i>Stephen C. Bondy</i></p> <p>7 Nanoparticles and Plants: From Toxicity to Activation of Growth 121<br /> <i>Mariya V. Khodakovskaya and Mohamed H. Lahiani</i></p> <p>8 Epigallocatechin-3-gallate (EGCG) in or on Nanoparticles: Enhanced Stability and Bioavailability of EGCG Encapsulated in Nanoparticles or Targeted Delivery of Gold Nanoparticles Coated with EGCG 131<br /> <i>Le Zhang, Shanshan Wu, Dongxu Wang, Xiaochun Wan and Jinsong Zhang</i></p> <p><b>Part Two </b><b>Nanomedicine </b><b>145</b></p> <p>9 Factors Affecting the Oral Bioavailability of Nanomaterials 147<br /> <i>Georgia K. Hinkley and Stephen M. Roberts</i></p> <p>10 Nanomedicine in Cancer Treatment 161<br /> <i>Ji-Eun Kim and Myung-Haing Cho</i></p> <p>11 Nanomedicine in Diabetes: Using Nanotechnology in Prevention and Management of Diabetes Mellitus 189<br /> <i>Radoslav Savi</i><i>ć</i><i> and Dusica Maysinger</i></p> <p>12 Inhalation Pathway as a Promising Portal of Entry: What Has to Be Considered in Designing New Nanomaterials for Biomedical Application? 205<br /> <i>Loretta M</i><i>ü</i><i>ller, Andrea D. Lehmann, Blair D. Johnston, Fabian Blank, Peter Wick, Alke Fink and Barbara Rothen-Rutishauser</i></p> <p>13 Nanomedicine for the Brain and the Eye: Disease Management in Poorly Accessible Compartments of the Body 223<br /> <i>Anna G. Cattaneo, Rosalba Gornati, Giovanni Bernardini, Enrico Sabbioni, Luigi Manzo and Mario Di Gioacchino</i></p> <p><b>Part Three </b><b>Stem Cell Toxicology </b><b>249</b></p> <p>14 Stem Cells in Toxicity Testing 251<br /> <i>Amy L. Inselman, Cheng Wang, Fang Liu and Deborah K. Hansen</i></p> <p>15 Human Stem-Cell-Derived Cardiomyocytes in Drug Discovery and Toxicity Testing 267<br /> <i>Korn</i><i>é</i><i>lia Szeb</i><i>é</i><i>nyi, Adrienn P</i><i>é</i><i>ntek, N</i><i>ó</i><i>ra Varga, Zsuzsa Erdei, Gerg˝o  V</i><i>ö</i><i>f</i><i>é</i><i>ly, Tam</i><i>á</i><i>s I. Orb</i><i>á</i><i>n, Bal</i><i>á</i><i>zs Sarkadi and </i><i>Á</i><i>gota Ap</i><i>á</i><i>ti</i></p> <p>16 Pluripotent Stem Cells as Tools to Assess Developmental Toxicity: Diversity Instead of Consolidation 299<br /> <i>Nicole R.L. Sparks and Nicole I. zur Nieden</i></p> <p>17 Impact of Various Nanosystems on Stem Cell Physiology 309<br /> <i>Anamaria Orza</i></p> <p>18 Predictive Mechanisms in Stem Cells: An <i>In Vitro </i>System-Based Method for Testing Carcinogenicity 337<br /> <i>Mireia Vilardell and Ralf Herwig</i></p> <p>19 Epigenetic Modifications and Stem Cell Toxicology: Searching for the Missing Link 347<br /> <i>Zacharoula Konsoula and Frank A. Barile</i></p> <p>20 Epigenetic Modeling and Stem Cells in Toxicology Testing 359<br /> <i>Sanket R. Gadhia and Frank A. Barile</i></p> <p>21 Use of Video Bioinformatics Tools in Stem Cell Toxicology 379<br /> <i>Prue Talbot, Nicole I. zur Nieden, Sabrina Lin, Ivann Martinez, Ben Guan and Bir Bhanu</i></p> <p>Author Index I</p> <p>Subject Index III</p>

<p>Dr. Saura C. Sahu Research Chemist, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration. Dr. Sahu is the US Editor for the Journal of Applied Toxicology and the editor of “Hepatotoxicity” (Wiley, 2007), “Toxicogenomics” (Wiley, 2008), “Nanotoxicity” (Wiley, 2009), and “Handbook of Systems Toxicology” (Wiley, 2011).</p>

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