Details

Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye

von: Amit Singh, Madhuri Kango-Singh
149,79 €
Verlag:	Springer
Format:	PDF
Veröffentl.:	14.09.2013
ISBN/EAN:	9781461482321
Sprache:	englisch
Anzahl Seiten:	368

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Beschreibungen

Titelbeschreibung

Undoubtedly, Drosophila melanogaster, fruit fly, has proved to be one of the most popular invertebrate model organisms, and the work horse for modern day biologists. Drosophila, a highly versatile model with a genetic legacy of more than a century, provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology focuses on how does a multi-cellular organism develop from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question, and led to other questions, such as the role of various genetics and cell biological pathways in regulating the crucial process of pattern formation and growth during organogenesis. Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This book will discuss molecular genetic mechanisms of pattern formation, mutations in axial patterning, Genetic regulation of growth in Drosophila eye, and more. There have been no titles in the past ten years covering this topic, thus an update is urgently needed.

Inhaltsverzeichnis

Early eye development: Specification and Determination.- Molecular genetic mechanisms of axial patterning: Mechanistic insights into generation of axes in the developing eye.- Catching the Next Wave: Patterning of the Drosophila Eye by the Morphogenetic Furrow.- Cell Morphogenesis.- Cell Polarity in Drosophila Retina.- Negative regulation for neural patterning in the Drosophila eye.- Cell Adhesion during Drosophila eye development.- Modulation of Developmental Signaling by the Proteostasis Network.- Drosophila eye as a model to study regulation of growth control: The discovery of size control pathways.- Contribution of the Drosophila eye to unraveling the basis of neurodegeneration.- Genetic regulation of early eye development in non-dipteran insects.- Development and evolution of the Drosophila Bolwig’s organ: a compound eye relict.- Index.

Back cover copy

Undoubtedly, Drosophila melanogaster, fruit fly, has proven to be one of the most popular invertebrate model organisms, and the work horse for modern day biologists. Drosophila, a highly versatile model with a genetic legacy of more than a century, provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology focuses on: how does a multi-cellular organism develop from a single-celled embryo? The discovery of the genes responsible for pattern formation has helped refine this question. Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This book will discuss molecular genetic mechanisms of pattern formation, axial patterning, growth regulation in Drosophila eye, and more.

Sonderbeitrag

Most updated title in the past ten years to cover this topicReviews all molecular genetic aspects of axial patterning in the drosophila eyeReviews the research and relates it to how it can transform our understanding of human diseases like cancer?Includes supplementary material: sn.pub/extras