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<p>List of Contributors ix</p> <p>Preface xv</p> <p>1 Introduction: Two Centuries of Progress in Transfusion Medicine 1<br /> <i>Walter H. (Sunny) Dzik and Michael F. Murphy</i></p> <p><b>Part I Basic Principles of Immunohaematology 11</b></p> <p>2 Essential Immunology for Transfusion Medicine 11<br /> <i>Jaap Jan Zwaginga and S. Marieke van Ham</i></p> <p>3 Human Blood Group Systems 20<br /> <i>Geoff Daniels</i></p> <p>4 Human Leucocyte Antigens 29<br /> <i>Cristina V. Navarrete and Colin J. Brown</i></p> <p>5 Platelet and Neutrophil Antigens 43<br /> <i>Brian R. Curtis</i></p> <p>6 Pretransfusion Testing and the Selection of Red Cell Products for Transfusion 58<br /> <i>Mark H. Yazer and Meghan Delaney</i></p> <p><b>Part II Complications of Transfusions 69</b></p> <p>7 Investigation of Acute Transfusion Reactions 69<br /> <i>Kathryn E. Webert and Nancy M. Heddle</i></p> <p>8 Haemolytic Transfusion Reactions 81<br /> <i>Edwin J. Massey, Robertson D. Davenport and Richard M. Kaufman</i></p> <p>9 Febrile and Allergic Transfusion Reactions 97<br /> <i>Mark K. Fung and Nancy M. Heddle</i></p> <p>10 Lung Injury and Pulmonary Oedema After Transfusion 108<br /> <i>Steven H. Kleinman and Daryl J. Kor</i></p> <p>11 Purported Adverse Effects of ‘Old Blood’ 118<br /> <i>Lirong Qu and Darrell J. Triulzi</i></p> <p>12 Transfusion‐Induced Immunomodulation 125<br /> <i>Amy E. Schmidt, Majed A. Refaai, Joanna M. Heal and Neil Blumberg</i></p> <p>13 Transfusion‐Associated Graft‐Versus‐Host Disease and Microchimerism 136<br /> <i>Beth H. Shaz, Richard O. Francis and Christopher D. Hillyer</i></p> <p>14 Posttransfusion Purpura 147<br /> <i>Michael F. Murphy</i></p> <p>15 Transfusion‐Transmitted Infections 153<br /> <i>Roger Y. Dodd and Susan L. Stramer</i></p> <p>16 Bacterial Contamination 168<br /> <i>Sandra Ramirez‐Arcos and Mindy Goldman</i></p> <p>17 Emerging Infections and Transfusion Safety 176<br /> <i>Roger Y. Dodd</i></p> <p><b>Part III Practice in Blood Centres and Hospitals 184</b></p> <p>18 Regulatory Aspects of Blood Transfusion 184<br /> <i>William G. Murphy, Louis M. Katz and Peter Flanagan</i></p> <p>19 The Role of Haemovigilance in Transfusion Safety 193<br /> <i>Katharine A. Downes and Barbee I. Whitaker</i></p> <p>20 Donors and Blood Collection 203<br /> <i>Marc Germain, Ellen McSweeney and William G. Murphy</i></p> <p>21 Blood Donation Testing and the Safety of the Blood Supply 215<br /> <i>Mindy Goldman</i></p> <p>22 Production and Storage of Blood Components 222<br /> <i>Marissa Li, Rebecca Cardigan, Stephen Thomas and Ralph Vassallo</i></p> <p>23 Blood Transfusion in Hospitals 233<br /> <i>Erica M. Wood, Mark H. Yazer and Michael F. Murphy</i></p> <p>24 Blood Transfusion in a Global Context 254<br /> <i>David J. Roberts, Alan D. Kitchen, Stephen P. Field, Imelda Bates,</i> <i>Jean Pierre Allain and Meghan Delaney</i></p> <p><b>Part IV Clinical Transfusion Practice 264</b></p> <p>25 Inherited and Acquired Coagulation Disorders 264<br /> <i>Irina Chibisov and Franklin Bontempo</i></p> <p>26 Massive Blood Loss 279<br /> <i>John R. Hess</i></p> <p>27 Blood Management in Acute Haemorrhage and Critical Care 287<br /> <i>Gavin J. Murphy, Nicola Curry, Nishith N. Patel and Timothy S. Walsh</i></p> <p>28 Point‐of‐Care Testing in Transfusion Medicine 302<br /> <i>Matthew D. Neal and Louis H. Alarcon</i></p> <p>29 Haematological Disease 312<br /> <i>Lise J. Estcourt, Simon J. Stanworth and Michael F. Murphy</i></p> <p>30 Blood Transfusion in the Management of Patients with Haemoglobinopathies 330<br /> <i>Enrico M. Novelli</i></p> <p>31 Heparin‐Induced Thrombocytopenia 341<br /> <i>Andreas Greinacher and Theodore E. Warkentin</i></p> <p>32 Immunodeficiency and Immunoglobulin Therapy 357<br /> <i>Siraj A. Misbah</i></p> <p>33 Transfusing Neonates and Infants 371<br /> <i>Ronald G. Strauss</i></p> <p><b>Part V Patient Blood Management 383</b></p> <p>34 Development of a Patient Blood Management Programme 383<br /> <i>Jonathan H. Waters</i></p> <p>35 Perioperative Patient Blood Management 393<br /> <i>Martin Rooms, Ravishankar Rao Baikady and Toby Richards</i></p> <p>36 Restrictive Transfusion Practice and How to Implement It 405<br /> <i>Lawrence Tim Goodnough and Neil Shah</i></p> <p>37 Using Data to Support Patient Blood Management 416<br /> Steven M. Frank and Jack O. Wasey</p> <p><b>Part VI Cellular and Tissue Therapy and Organ Transplantation 429</b></p> <p>38 Regulation and Accreditation in Cellular Therapy 429<br /> <i>Zbigniew (Ziggy) M. Szczepiorkowski and Daniel Hollyman</i></p> <p>39 Stem Cell Collection and Therapeutic Apheresis 442<br /> <i>Khaled El‐Ghariani and Zbigniew (Ziggy) M. Szczepiorkowski</i></p> <p>40 Haemopoietic Stem Cell Processing and Storage 455<br /> <i>Hira Mian, Ronan Foley and Pamela O’Hoski</i></p> <p>41 Haematopoietic Stem Cell Transplantation 466<br /> <i>Robert D. Danby, Rachel Protheroe and David J. Roberts</i></p> <p>42 Cord Blood Transplantation 477<br /> <i>Rachael Hough and Robert D. Danby</i></p> <p>43 Recent Advances in Clinical Cellular Immunotherapy 490<br /> <i>Mark W. Lowdell and Emma Morris</i></p> <p>44 Tissue Banking 500 <br /> <i>Akila Chandrasekar, Paul Rooney and John N. Kearney</i></p> <p><b>Part VII Development of the Evidence Base for Transfusion 508</b></p> <p>45 Observational and Interventional Trials in Transfusion Medicine 508<br /> <i>Alan T. Tinmouth, Dean Fergusson and Paul C. Hebert</i></p> <p>46 Getting the Most Out of the Evidence for Transfusion Medicine 520<br /> <i>Simon J. Stanworth, Susan J. Brunskill, Carolyn Doree and Sally Hopewell</i></p> <p>47 A Primer on Biostatistics 533<br /> <i>Andrew W. Shih and Nancy M. Heddle</i></p> <p>48 A Primer on Health Economics 549<br /> <i>Seema Kacker and Aaron A. R. Tobian</i></p> <p>49 Scanning the Future of Transfusion Medicine 560<br /> <i>Jay E. Menitove, Paul M. Ness and Edward L. Snyder</i></p> <p>Index 572 </p>

<p>“This is a great book if you want a truly practical and up-to-date guide to transfusion medicine. This is great for transfusion medicine practitioners to quickly get up to speed on what is happening in the field and/or use as a thorough and concise review for periodic competency or proficiency exams” <b>Valerie L. Ng, PhD MD, Alameda County Medical Center/Highland Hospital on behalf of Doody’s</b></p>

<p> <b>MICHAEL F. MURPHY,</b> Professor of Blood Transfusion Medicine, University of Oxford, UK <p><b>DAVID J. ROBERTS,</b> Professor of Haematology, University of Oxford, UK <p><b>MARK H. YAZER,</b> Professor of Pathology, University of Pittsburgh, USA; Adjunct Professor of Clinical Immunology, University of Southern Denmark, Denmark

<p>The fifth edition of this practical textbook on transfusion medicine has been thoroughly revised with the latest in scientific and technological developments and edited by a leading team of international expert haematologists, including a new co-editor Mark H. Yazer MD. <p>The concise and comprehensive content covers the diverse field of transfusion medicine including; the fields of haemostasis, immunology, transplantation and cellular engineering; apheresis technology; treatment using recombinant and plasma-derived plasma proteins; and the daily use of blood components in clinical medicine. Such is the reach of the field that without transfusion resources ensuring the provision of a safe blood supply very little of modern surgery and medicine could be accomplished. The seven sections of this book guide the reader systematically through the key areas of the speciality; principles of transfusion medicine; complications of transfusion; practice in blood centres and hospitals; clinical transfusion practice; patient blood management; cellular and tissue therapy and organ transplantation; and development of the evidence base for transfusion. <p>This book offers: <ul> <li>A succinct and user-friendly resource with key points, charts and algorithms</li> <li>Discussion of practice in blood centres and hospitals, including regulatory aspects, transfusion safety, production and storage, donor care, and blood transfusion in a global context</li> <li>Coverage of cellular and tissue therapies and organ transplantation, including stem cell collection and haematopoietic stem cell processing and storage</li> <li>Review of the development of the evidence base for transfusion medicine</li> <li>Content on the alternatives to transfusions, and practical clinical advice</li> </ul><br> <p>This book is ideal for trainee or resident haematologists revising for examinations and as a reference source for clinical and scientific staff working in the field of transfusion medicine.

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